Targeting and pharmacology of an anti-IL13Rα2 antibody and antibody-drug conjugate in a melanoma xenograft model

IL13Rα2 is a cell surface tumor antigen that is overexpressed in multiple tumor types. Here, we studied biodistribution and targeting potential of an anti-IL13Rα2 antibody (Ab) and anti-tumor activity of anti-IL13Rα2-antibody-drug conjugate (ADC). The anti-IL13Rα2 Ab was labeled with fluorophore AF6...

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Detalles Bibliográficos
Autores principales: Gupta, Parul, Jiang, Ziyue Karen, Yang, Bing, Manzuk, Lisa, Rosfjord, Edward, Yao, Johnny, Lemon, Luanna, Noorbehesht, Kavon, David, John, Puthenveetil, Sujiet, Casavant, Jeffrey M., Muszynska, Elwira, Li, Fengping, Leal, Mauricio, Sapra, Puja, Giddabasappa, Anand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344738/
https://www.ncbi.nlm.nih.gov/pubmed/34347577
http://dx.doi.org/10.1080/19420862.2021.1958662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344738/
https://www.ncbi.nlm.nih.gov/pubmed/34347577
http://dx.doi.org/10.1080/19420862.2021.1958662

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