Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer

Hypoxia develops in germinal centers (GCs) induced by model antigens; however, it is unknown whether tumor-reactive GCs are also hypoxic. We identified GC hypoxia in lymph nodes (LNs) draining murine mammary tumors and lethally irradiated tumor cells, and found that hypoxia is associated with the le...

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Detalles Bibliográficos
Autores principales: Firmino, Natalie S, Cederberg, Rachel A, Lee, Che-Min, Shi, Rocky, Wadsworth, Brennan J, Franks, S Elizabeth, Thomas, Kiersten N, Decotret, Lisa R, Bennewith, Kevin L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344742/
https://www.ncbi.nlm.nih.gov/pubmed/34377597
http://dx.doi.org/10.1080/2162402X.2021.1959978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344742/
https://www.ncbi.nlm.nih.gov/pubmed/34377597
http://dx.doi.org/10.1080/2162402X.2021.1959978

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