Cargando…

Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer

Hypoxia develops in germinal centers (GCs) induced by model antigens; however, it is unknown whether tumor-reactive GCs are also hypoxic. We identified GC hypoxia in lymph nodes (LNs) draining murine mammary tumors and lethally irradiated tumor cells, and found that hypoxia is associated with the le...

Descripción completa

Detalles Bibliográficos
Autores principales:	Firmino, Natalie S, Cederberg, Rachel A, Lee, Che-Min, Shi, Rocky, Wadsworth, Brennan J, Franks, S Elizabeth, Thomas, Kiersten N, Decotret, Lisa R, Bennewith, Kevin L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344742/ https://www.ncbi.nlm.nih.gov/pubmed/34377597 http://dx.doi.org/10.1080/2162402X.2021.1959978

Ejemplares similares

Eosinophils Decrease Pulmonary Metastatic Mammary Tumor Growth
por: Cederberg, Rachel A., et al.
Publicado: (2022)

Development and validation of an advanced ex vivo brain slice invasion assay to model glioblastoma cell invasion into the complex brain microenvironment
por: Decotret, Lisa R., et al.
Publicado: (2023)

Unlocking the therapeutic potential of primary tumor-draining lymph nodes
por: Rotman, Jossie, et al.
Publicado: (2019)

Immune Checkpoint Therapy: Tumor Draining Lymph Nodes in the Spotlights
por: Fransen, Marieke F., et al.
Publicado: (2021)

Chemotherapy but Not the Tumor Draining Lymph Nodes Determine the Immunotherapy Response in Secondary Tumors
por: Zhao, Xianda, et al.
Publicado: (2020)

Mechanisms of Tumor-Induced Lymphovascular Niche Formation in Draining Lymph Nodes
por: Commerford, Catharina D., et al.
Publicado: (2018)

Tumor-Draining Lymph Secretome En Route to the Regional Lymph Node in Breast Cancer Metastasis
por: Mohammed, Sulma I, et al.
Publicado: (2020)

Metinel Node—The First Lymph Node Draining a Metastasis—Contains Tumor-Reactive Lymphocytes
por: Dahl, Kjell, et al.
Publicado: (2008)

Regulatory B cells preferentially accumulate in tumor-draining lymph nodes and promote tumor growth
por: Ganti, Sheila N., et al.
Publicado: (2015)

Induction of anergic or regulatory tumor-specific CD4(+) T cells in the tumor-draining lymph node
por: Alonso, Ruby, et al.
Publicado: (2018)

Coimmunomodulation of tumor and tumor-draining lymph nodes during in situ vaccination promotes antitumor immunity
por: Jeong, Moonkyoung, et al.
Publicado: (2022)

Microenvironment of Tumor-Draining Lymph Nodes: Opportunities for Liposome-Based Targeted Therapy
por: Chandrasekaran, Siddarth, et al.
Publicado: (2014)

Yeast-derived nanoparticles remodel the immunosuppressive microenvironment in tumor and tumor-draining lymph nodes to suppress tumor growth
por: Xu, Jialu, et al.
Publicado: (2022)

Receptor-type protein tyrosine phosphatase alpha (PTPα) mediates MMP14 localization and facilitates triple-negative breast cancer cell invasion
por: Decotret, Lisa R., et al.
Publicado: (2021)

Immune-cancer interactions in tumors and tumor-draining lymph nodes: Novel prognostic indicators for breast cancer
por: Mansfield, James, et al.
Publicado: (2014)

Lymphocytes in tumor-draining lymph nodes co-cultured with autologous tumor cells for adoptive cell therapy
por: Okamura, Kazumi, et al.
Publicado: (2022)

Distinct mechanisms of B and T lymphocyte accumulation generate tumor-draining lymph node hypertrophy
por: Habenicht, Lauren M., et al.
Publicado: (2016)

Disrupted fibroblastic reticular cells and interleukin-7 expression in tumor draining lymph nodes
por: Gao, Jianbao, et al.
Publicado: (2017)

Tumor-draining lymph node is important for a robust abscopal effect stimulated by radiotherapy
por: Buchwald, Zachary S, et al.
Publicado: (2020)

Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients
por: Núñez, Nicolas Gonzalo, et al.
Publicado: (2020)

IFNAR1 Deficiency Impairs Immunostimulatory Properties of Neutrophils in Tumor-Draining Lymph Nodes
por: Hussain, Timon, et al.
Publicado: (2022)

Requirement of Innate Immunity in Tumor-Bearing Mice Cured by Adoptive Immunotherapy Using Tumor-Draining Lymph Nodes
por: Ammori, John, et al.
Publicado: (2015)

Neutrophils in primary gastric tumors are correlated with neutrophil infiltration in tumor-draining lymph nodes and the systemic inflammatory response
por: Hiramatsu, Soichiro, et al.
Publicado: (2018)

ACKR4 in Tumor Cells Regulates Dendritic Cell Migration to Tumor-Draining Lymph Nodes and T-Cell Priming
por: Wangmo, Dechen, et al.
Publicado: (2021)

Quantitative, Architectural Analysis of Immune Cell Subsets in Tumor-Draining Lymph Nodes from Breast Cancer Patients and Healthy Lymph Nodes
por: Setiadi, A. Francesca, et al.
Publicado: (2010)

slanDCs in carcinoma-draining lymph nodes
por: Vermi, William, et al.
Publicado: (2014)

Morphology of Immunomodulation in Breast Cancer Tumor Draining Lymph Nodes Depends on Stage and Intrinsic Subtype
por: Seidl, Maximilian, et al.
Publicado: (2018)

Single-cell analysis reveals immune modulation and metabolic switch in tumor-draining lymph nodes
por: Li, Yen-Liang, et al.
Publicado: (2020)

Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma
por: Riedel, Angela, et al.
Publicado: (2022)

CD8-positive memory T cells in tumor-draining lymph nodes of patients with breast cancer
por: Vahidi, Yasmin, et al.
Publicado: (2020)

Correction: Tumor-draining lymph node is important for a robust abscopal effect stimulated by radiotherapy
Publicado: (2021)

Pivotal roles of tumor‐draining lymph nodes in the abscopal effects from combined immunotherapy and radiotherapy
por: Liu, Zhaoyun, et al.
Publicado: (2022)

Immunomodulatory Responses of Subcapsular Sinus Floor Lymphatic Endothelial Cells in Tumor-Draining Lymph Nodes
por: Sibler, Eliane, et al.
Publicado: (2022)

Boiling histotripsy induces dendritic cell activation and acquisition of antigen in tumor draining lymph nodes
por: Thim, Eric A., et al.
Publicado: (2023)

Cryo-ablation improves anti-tumor immunity through recovering tumor educated dendritic cells in tumor-draining lymph nodes
por: He, Xiao-Zheng, et al.
Publicado: (2015)

Bladder-draining lymph nodes support germinal center B cell responses during urinary tract infection in mice
por: Hawas, Sophia, et al.
Publicado: (2023)

A Physiologically Based Pharmacokinetic Framework for Quantifying Antibody Distribution Gradients from Tumors to Tumor-Draining Lymph Nodes
por: Salgado, Eric, et al.
Publicado: (2022)

B cells in tumor draining lymph nodes act as efficient antigen presenting cells in cancer patients
por: Zirakzadeh, A Ali, et al.
Publicado: (2015)

Tumor‐associated neutrophils (TANs) in human carcinoma‐draining lymph nodes: a novel TAN compartment
por: Lonardi, Silvia, et al.
Publicado: (2021)

Automated detection of vascular remodeling in tumor‐draining lymph nodes by the deep‐learning tool HEV‐finder
por: Bekkhus, Tove, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ihah48bih2v2m6oqdrlqolj8r7