Synthetic Lethality Screening Highlights Colorectal Cancer Vulnerability to Concomitant Blockade of NEDD8 and EGFR Pathways

SIMPLE SUMMARY: Identification of effective therapies for clinically aggressive, treatment-resistant colorectal cancer (CRC) remains an unmet clinical need. Targeted therapies against the epidermal growth factor receptor (EGFR) signaling axis lead to clinical benefits only in a small fraction of pat...

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Detalles Bibliográficos
Autores principales: Invrea, Federica, Punzi, Simona, Petti, Consalvo, Minelli, Rosalba, Peoples, Michael D., Bristow, Christopher A., Vurchio, Valentina, Corrado, Alessia, Bragoni, Alberto, Marchiò, Caterina, Bertotti, Andrea, Trusolino, Livio, Bardelli, Alberto, Isella, Claudio, Carugo, Alessandro, Draetta, Giulio F., Medico, Enzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345131/
https://www.ncbi.nlm.nih.gov/pubmed/34359705
http://dx.doi.org/10.3390/cancers13153805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345131/
https://www.ncbi.nlm.nih.gov/pubmed/34359705
http://dx.doi.org/10.3390/cancers13153805

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