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Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies

SIMPLE SUMMARY: Cells respond to genotoxic stress through complex protein pathways called DNA damage response (DDR). These mechanisms ensure the preservation of genomic integrity and activate DNA repair, cell cycle regulation, and, ultimately, programmed cell death. When altered, the DDR protein net...

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Detalles Bibliográficos
Autores principales: Molinaro, Caroline, Martoriati, Alain, Cailliau, Katia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345162/
https://www.ncbi.nlm.nih.gov/pubmed/34359720
http://dx.doi.org/10.3390/cancers13153819