WIP1 Inhibition by GSK2830371 Potentiates HDM201 through Enhanced p53 Phosphorylation and Activation in Liver Adenocarcinoma Cells

SIMPLE SUMMARY: Patients with advanced intrahepatic cholangiocarcinoma (iCCA) have a very poor prognosis, and no targeted therapy is approved for advanced iCCA. A therapeutic strategy for wild-type p53 cancers is the reactivation of p53 by inhibition of its the negative regulators, MDM2, and WIP1. I...

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Detalles Bibliográficos
Autores principales: Wu, Chiao-En, Huang, Chen-Yang, Chen, Chiao-Ping, Pan, Yi-Ru, Chang, John Wen-Cheng, Chen, Jen-Shi, Yeh, Chun-Nan, Lunec, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345393/
https://www.ncbi.nlm.nih.gov/pubmed/34359777
http://dx.doi.org/10.3390/cancers13153876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345393/
https://www.ncbi.nlm.nih.gov/pubmed/34359777
http://dx.doi.org/10.3390/cancers13153876

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