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Inhibitors Targeting CDK9 Show High Efficacy against Osimertinib and AMG510 Resistant Lung Adenocarcinoma Cells

SIMPLE SUMMARY: Non-small cell lung cancer accounts for 80% of all lung cancer cases. While a subset of non-small cell lung cancer patients respond to immunotherapy, those who are treated with chemotherapy or targeted therapy develop resistance to the drugs. Thus, novel therapeutic strategies are ne...

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Detalles Bibliográficos
Autores principales: Padmanabhan, Jaya, Saha, Biswarup, Powell, Chase, Mo, Qianxing, Perez, Bradford A., Chellappan, Srikumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345430/
https://www.ncbi.nlm.nih.gov/pubmed/34359807
http://dx.doi.org/10.3390/cancers13153906