Chromosomal Translocations in NK-Cell Lymphomas Originate from Inter-Chromosomal Contacts of Active rDNA Clusters Possessing Hot Spots of DSBs

SIMPLE SUMMARY: There are nine DSB hot spots located in the non-transcribed spacer of human rDNA units. Circular chromosome conformation capture data indicate that the rDNA clusters often shape contact with a specific set of chromosomal regions containing genes controlling differentiation and cancer...

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Detalles Bibliográficos
Autores principales: Tchurikov, Nickolai A., Uroshlev, Leonid A., Klushevskaya, Elena S., Alembekov, Ildar R., Lagarkova, Maria A., Kravatskaya, Galina I., Makeev, Vsevolod Y., Kravatsky, Yuri V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345467/
https://www.ncbi.nlm.nih.gov/pubmed/34359791
http://dx.doi.org/10.3390/cancers13153889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345467/
https://www.ncbi.nlm.nih.gov/pubmed/34359791
http://dx.doi.org/10.3390/cancers13153889

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