PKM2 Regulates HSP90-Mediated Stability of the IGF-1R Precursor Protein and Promotes Cancer Cell Survival during Hypoxia

SIMPLE SUMMARY: Generally, IGF-1R is overexpressed in most solid tumors, and its expression is significantly associated with poor prognosis in cancer patients. However, IGF-1R gene amplification events are extremely rare in tumors. It is, therefore, necessary to define the mechanism underlying IGR-1...

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Detalles Bibliográficos
Autores principales: Koo, Han, Byun, Sangwon, Seo, Jieun, Jung, Yuri, Lee, Dong Chul, Cho, Jung Hee, Park, Young Soo, Yeom, Young Il, Park, Kyung Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345735/
https://www.ncbi.nlm.nih.gov/pubmed/34359752
http://dx.doi.org/10.3390/cancers13153850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345735/
https://www.ncbi.nlm.nih.gov/pubmed/34359752
http://dx.doi.org/10.3390/cancers13153850

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