An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation?

Functional mechanisms remain unknown for most genetic loci associated to complex human traits and diseases. In this study, we first mapped trans-eQTLs in a data set of primary monocytes stimulated with LPS, and discovered that a risk variant for autoimmune disease, rs17622517 in an intron of C5ORF56...

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Detalles Bibliográficos
Autores principales: Brandt, Margot, Kim-Hellmuth, Sarah, Ziosi, Marcello, Gokden, Alper, Wolman, Aaron, Lam, Nora, Recinos, Yocelyn, Daniloski, Zharko, Morris, John A., Hornung, Veit, Schumacher, Johannes, Lappalainen, Tuuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345867/
https://www.ncbi.nlm.nih.gov/pubmed/34314424
http://dx.doi.org/10.1371/journal.pgen.1009684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345867/
https://www.ncbi.nlm.nih.gov/pubmed/34314424
http://dx.doi.org/10.1371/journal.pgen.1009684

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