Evaluating the antidiabetic effects of R-verapamil in type 1 and type 2 diabetes mellitus mouse models

The global incidence of diabetes mellitus (DM) is increasing. Types 1 and 2 DM are associated with declining β-cell function. Verapamil (50% S-verapamil and 50% R-verapamil) can treat DM by downregulating thioredoxin-interacting protein (TXNIP), which induces islet β-cell apoptosis. However, it may...

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Detalles Bibliográficos
Autores principales: Chen, Yu-Syuan, Weng, Shao-Ju, Chang, Shu-Hsien, Li, Rou-Ying, Shane, Guang-Tzuu, Hsu, Jui-Pao, Yeh, Sheng-Wen, Chang, Ai-Ching, Lee, Meng-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345870/
https://www.ncbi.nlm.nih.gov/pubmed/34358247
http://dx.doi.org/10.1371/journal.pone.0255405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345870/
https://www.ncbi.nlm.nih.gov/pubmed/34358247
http://dx.doi.org/10.1371/journal.pone.0255405

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