Global Deletion of 11β-HSD1 Prevents Muscle Wasting Associated with Glucocorticoid Therapy in Polyarthritis

Glucocorticoids provide indispensable anti-inflammatory therapies. However, metabolic adverse effects including muscle wasting restrict their use. The enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) modulates peripheral glucocorticoid responses through pre-receptor metabolism. This stud...

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Detalles Bibliográficos
Autores principales: Webster, Justine M., Sagmeister, Michael S., Fenton, Chloe G., Seabright, Alex P., Lai, Yu-Chiang, Jones, Simon W., Filer, Andrew, Cooper, Mark S., Lavery, Gareth G., Raza, Karim, Langen, Ramon, Hardy, Rowan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346140/
https://www.ncbi.nlm.nih.gov/pubmed/34360594
http://dx.doi.org/10.3390/ijms22157828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346140/
https://www.ncbi.nlm.nih.gov/pubmed/34360594
http://dx.doi.org/10.3390/ijms22157828

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