In Silico Structural Modeling and Analysis of Interactions of Tremellomycetes Cytochrome P450 Monooxygenases CYP51s with Substrates and Azoles

Cytochrome P450 monooxygenase CYP51 (sterol 14α-demethylase) is a well-known target of the azole drug fluconazole for treating cryptococcosis, a life-threatening fungal infection in immune-compromised patients in poor countries. Studies indicate that mutations in CYP51 confer fluconazole resistance...

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Detalles Bibliográficos
Autores principales: Akapo, Olufunmilayo Olukemi, Macnar, Joanna M., Kryś, Justyna D., Syed, Puleng Rosinah, Syed, Khajamohiddin, Gront, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346148/
https://www.ncbi.nlm.nih.gov/pubmed/34360577
http://dx.doi.org/10.3390/ijms22157811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346148/
https://www.ncbi.nlm.nih.gov/pubmed/34360577
http://dx.doi.org/10.3390/ijms22157811

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