Cargando…

Investigating LMNA-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

LMNA-related dilated cardiomyopathy is an inherited heart disease caused by mutations in the LMNA gene encoding for lamin A/C. The disease is characterized by left ventricular enlargement and impaired systolic function associated with conduction defects and ventricular arrhythmias. We hypothesized t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shemer, Yuval, Mekies, Lucy N., Ben Jehuda, Ronen, Baskin, Polina, Shulman, Rita, Eisen, Binyamin, Regev, Danielle, Arbustini, Eloisa, Gerull, Brenda, Gherghiceanu, Mihaela, Gottlieb, Eyal, Arad, Michael, Binah, Ofer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346174/ https://www.ncbi.nlm.nih.gov/pubmed/34360639 http://dx.doi.org/10.3390/ijms22157874

Ejemplares similares

Depressed β‐adrenergic inotropic responsiveness and intracellular calcium handling abnormalities in Duchenne Muscular Dystrophy patients’ induced pluripotent stem cell–derived cardiomyocytes
por: Mekies, Lucy N., et al.
Publicado: (2021)

Electrophysiological abnormalities in induced pluripotent stem cell‐derived cardiomyocytes generated from Duchenne muscular dystrophy patients
por: Eisen, Binyamin, et al.
Publicado: (2019)

Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy
por: Schick, Revital, et al.
Publicado: (2018)

Investigating the cardiac pathology of SCO2‐mediated hypertrophic cardiomyopathy using patients induced pluripotent stem cell–derived cardiomyocytes
por: Hallas, Tova, et al.
Publicado: (2017)

Bioenergetic and Metabolic Impairments in Induced Pluripotent Stem Cell-Derived Cardiomyocytes Generated from Duchenne Muscular Dystrophy Patients
por: Willi, Lubna, et al.
Publicado: (2022)

Drug Development and the Use of Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Disease Modeling and Drug Toxicity Screening
por: Ovics, Paz, et al.
Publicado: (2020)

A Method Sustaining the Bioelectric, Biophysical, and Bioenergetic Function of Cultured Rabbit Atrial Cells
por: Kirschner Peretz, Noa, et al.
Publicado: (2017)

Modeling Duchenne Muscular Dystrophy Cardiomyopathy with Patients’ Induced Pluripotent Stem-Cell-Derived Cardiomyocytes
por: Eisen, Binyamin, et al.
Publicado: (2023)

Functional abnormalities in iPSC-derived cardiomyocytes generated from CPVT1 and CPVT2 patients carrying ryanodine or calsequestrin mutations
por: Novak, Atara, et al.
Publicado: (2015)

Cardiomyocytes derived from human embryonic and induced pluripotent stem cells: comparative ultrastructure
por: Gherghiceanu, Mihaela, et al.
Publicado: (2011)

Cardiomyocyte Proliferative Capacity Is Restricted in Mice With Lmna Mutation
por: Onoue, Kenji, et al.
Publicado: (2021)

Deficient Lmna in fibroblasts: an emerging role of non-cardiomyocytes in DCM
por: Wang, Xinjie, et al.
Publicado: (2022)

LMNA-related dilated cardiomyopathy
por: Vaikhanskaya, Tatiyana, et al.
Publicado: (2014)

Cardiomyocyte-Specific Expression of Lamin A Improves Cardiac Function in Lmna (−/−) Mice
por: Frock, Richard L., et al.
Publicado: (2012)

Integrated analysis reveals the alterations that LMNA interacts with euchromatin in LMNA mutation-associated dilated cardiomyopathy
por: Zhang, Xiaolin, et al.
Publicado: (2021)

cAMP-PKA signaling modulates the automaticity of human iPSC-derived cardiomyocytes
por: Mazgaoker, Savyon, et al.
Publicado: (2022)

Correction: Cardiomyocyte-Specific Expression of Lamin A Improves Cardiac Function in Lmna (−/−) Mice
por: Frock, Richard L., et al.
Publicado: (2012)

Familial cardiomyopathy caused by a novel heterozygous mutation in the gene LMNA (c.1434dupG): a cardiac MRI-augmented segregation study
por: ALFARIH, MASHAEL, et al.
Publicado: (2019)

Modeling Catecholaminergic Polymorphic Ventricular Tachycardia using Induced Pluripotent Stem Cell-derived Cardiomyocytes
por: Novak, Atara, et al.
Publicado: (2012)

Phenotypic Variability in iPSC-Induced Cardiomyocytes and Cardiac Fibroblasts Carrying Diverse LMNA Mutations
por: Yang, Jiajia, et al.
Publicado: (2021)

Corrigendum: Phenotypic variability in iPSC-induced cardiomyocytes and cardiac fibroblasts carrying diverse LMNA mutations
por: Yang, Jiajia, et al.
Publicado: (2022)

Activation of PDGF Pathway Links LMNA Mutation to Dilated Cardiomyopathy
por: Lee, Jaecheol, et al.
Publicado: (2019)

Epigenetics in LMNA-Related Cardiomyopathy
por: Wang, Yinuo, et al.
Publicado: (2023)

Cardiomyocytes generated from CPVT(D307H) patients are arrhythmogenic in response to β-adrenergic stimulation
por: Novak, Atara, et al.
Publicado: (2012)

Upregulation of the aging related LMNA splice variant progerin in dilated cardiomyopathy
por: Messner, Moritz, et al.
Publicado: (2018)

LMNA Gene Mutation Presenting with Ventricular Tachycardia in the Absence of Dilated Cardiomyopathy
por: Poudel, Binod, et al.
Publicado: (2022)

A novel LMNA mutation identified in a Japanese patient with LMNA-associated congenital muscular dystrophy
por: Ishiyama, Akihiko, et al.
Publicado: (2018)

Metreleptin therapy in LMNA-linked lipodystrophies
por: Vatier, Camille, et al.
Publicado: (2015)

Exploring the Crosstalk Between LMNA and Splicing Machinery Gene Mutations in Dilated Cardiomyopathy
por: Zahr, Hind C., et al.
Publicado: (2018)

Inherited dilated cardiomyopathy in a large Moroccan family caused by LMNA mutation
por: Adadi, Najlae, et al.
Publicado: (2018)

Molecular characterization and functional properties of cardiomyocytes derived from human inducible pluripotent stem cells
por: Germanguz, Igal, et al.
Publicado: (2011)

Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and LMNA and SCN5A Mutations
por: Mahajan, Asha M., et al.
Publicado: (2021)

Irisin levels in LMNA-mutated lipodystrophic syndromes
por: Bensmaine, Faiza, et al.
Publicado: (2015)

LMNA mutations in Polish patients with dilated cardiomyopathy: prevalence, clinical characteristics, and in vitro studies
por: Saj, Michal, et al.
Publicado: (2013)

Modeling of LMNA-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cells
por: Shah, Disheet, et al.
Publicado: (2019)

Novel linkage of LMNA Single Nucleotide Polymorphism with Dilated Cardiomyopathy in an Indian case study
por: Banerjee, Avinanda, et al.
Publicado: (2015)

Megakaryocyte- and erythroblast-specific cell-free DNA patterns in plasma and platelets reflect thrombopoiesis and erythropoiesis levels
por: Moss, Joshua, et al.
Publicado: (2023)

SNTA1 gene rescues ion channel function and is antiarrhythmic in cardiomyocytes derived from induced pluripotent stem cells from muscular dystrophy patients
por: Jimenez-Vazquez, Eric N, et al.
Publicado: (2022)

Cardiomyocyte precursors and telocytes in epicardial stem cell niche: electron microscope images
por: Gherghiceanu, Mihaela, et al.
Publicado: (2010)

LMNA-mutated Rabbits: A Model of Premature Aging Syndrome with Muscular Dystrophy and Dilated Cardiomyopathy
por: Sui, Tingting, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_iv433h077kea9jgghht6rhvtni