Nanocapsules modify membrane interaction of polymyxin B to enable safe systemic therapy of Gram-negative sepsis

Systemic therapy of Gram-negative sepsis remains challenging. Polymyxin B (PMB) is well suited for sepsis therapy due to the endotoxin affinity and antibacterial activity. However, the dose-limiting toxicity has limited its systemic use in sepsis patients. For safe systemic use of PMB, we have devel...

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Detalles Bibliográficos
Autores principales: Yuk, Simseok A., Kim, Hyungjun, Abutaleb, Nader S., Dieterly, Alexandra M., Taha, Maie S., Tsifansky, Michael D., Lyle, L. Tiffany, Seleem, Mohamed N., Yeo, Yoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346222/
https://www.ncbi.nlm.nih.gov/pubmed/34362742
http://dx.doi.org/10.1126/sciadv.abj1577

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346222/
https://www.ncbi.nlm.nih.gov/pubmed/34362742
http://dx.doi.org/10.1126/sciadv.abj1577

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