Cargando…
Discovery-stage identification of drug-like antibodies using emerging experimental and computational methods
There is intense and widespread interest in developing monoclonal antibodies as therapeutic agents to treat diverse human disorders. During early-stage antibody discovery, hundreds to thousands of lead candidates are identified, and those that lack optimal physical and chemical properties must be de...
Autores principales: | Makowski, Emily K., Wu, Lina, Gupta, Priyanka, Tessier, Peter M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346245/ https://www.ncbi.nlm.nih.gov/pubmed/34313532 http://dx.doi.org/10.1080/19420862.2021.1895540 |
Ejemplares similares
-
Toward Drug-Like Multispecific Antibodies by Design
por: Sawant, Manali S., et al.
Publicado: (2020) -
Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties
por: Svilenov, Hristo L., et al.
Publicado: (2023) -
Highly sensitive detection of antibody nonspecific interactions using flow cytometry
por: Makowski, Emily K., et al.
Publicado: (2021) -
Emerging Computational Methods for the Rational Discovery
of Allosteric Drugs
por: Wagner, Jeffrey R., et al.
Publicado: (2016) -
Computational approaches in target identification and drug discovery
por: Katsila, Theodora, et al.
Publicado: (2016)