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Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study
The ability to investigate therapeutic interventions in animal models of neurodegenerative diseases depends on extensive characterization of the model(s) being used. There are numerous models that have been generated to study Alzheimer’s disease (AD) and the underlying pathogenesis of the disease. W...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346252/ https://www.ncbi.nlm.nih.gov/pubmed/34366832 http://dx.doi.org/10.3389/fnagi.2021.713726 |
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author | Oblak, Adrian L. Lin, Peter B. Kotredes, Kevin P. Pandey, Ravi S. Garceau, Dylan Williams, Harriet M. Uyar, Asli O’Rourke, Rita O’Rourke, Sarah Ingraham, Cynthia Bednarczyk, Daria Belanger, Melisa Cope, Zackary A. Little, Gabriela J. Williams, Sean-Paul G. Ash, Carl Bleckert, Adam Ragan, Tim Logsdon, Benjamin A. Mangravite, Lara M. Sukoff Rizzo, Stacey J. Territo, Paul R. Carter, Gregory W. Howell, Gareth R. Sasner, Michael Lamb, Bruce T. |
author_facet | Oblak, Adrian L. Lin, Peter B. Kotredes, Kevin P. Pandey, Ravi S. Garceau, Dylan Williams, Harriet M. Uyar, Asli O’Rourke, Rita O’Rourke, Sarah Ingraham, Cynthia Bednarczyk, Daria Belanger, Melisa Cope, Zackary A. Little, Gabriela J. Williams, Sean-Paul G. Ash, Carl Bleckert, Adam Ragan, Tim Logsdon, Benjamin A. Mangravite, Lara M. Sukoff Rizzo, Stacey J. Territo, Paul R. Carter, Gregory W. Howell, Gareth R. Sasner, Michael Lamb, Bruce T. |
author_sort | Oblak, Adrian L. |
collection | PubMed |
description | The ability to investigate therapeutic interventions in animal models of neurodegenerative diseases depends on extensive characterization of the model(s) being used. There are numerous models that have been generated to study Alzheimer’s disease (AD) and the underlying pathogenesis of the disease. While transgenic models have been instrumental in understanding AD mechanisms and risk factors, they are limited in the degree of characteristics displayed in comparison with AD in humans, and the full spectrum of AD effects has yet to be recapitulated in a single mouse model. The Model Organism Development and Evaluation for Late-Onset Alzheimer’s Disease (MODEL-AD) consortium was assembled by the National Institute on Aging (NIA) to develop more robust animal models of AD with increased relevance to human disease, standardize the characterization of AD mouse models, improve preclinical testing in animals, and establish clinically relevant AD biomarkers, among other aims toward enhancing the translational value of AD models in clinical drug design and treatment development. Here we have conducted a detailed characterization of the 5XFAD mouse, including transcriptomics, electroencephalogram, in vivo imaging, biochemical characterization, and behavioral assessments. The data from this study is publicly available through the AD Knowledge Portal. |
format | Online Article Text |
id | pubmed-8346252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83462522021-08-07 Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study Oblak, Adrian L. Lin, Peter B. Kotredes, Kevin P. Pandey, Ravi S. Garceau, Dylan Williams, Harriet M. Uyar, Asli O’Rourke, Rita O’Rourke, Sarah Ingraham, Cynthia Bednarczyk, Daria Belanger, Melisa Cope, Zackary A. Little, Gabriela J. Williams, Sean-Paul G. Ash, Carl Bleckert, Adam Ragan, Tim Logsdon, Benjamin A. Mangravite, Lara M. Sukoff Rizzo, Stacey J. Territo, Paul R. Carter, Gregory W. Howell, Gareth R. Sasner, Michael Lamb, Bruce T. Front Aging Neurosci Neuroscience The ability to investigate therapeutic interventions in animal models of neurodegenerative diseases depends on extensive characterization of the model(s) being used. There are numerous models that have been generated to study Alzheimer’s disease (AD) and the underlying pathogenesis of the disease. While transgenic models have been instrumental in understanding AD mechanisms and risk factors, they are limited in the degree of characteristics displayed in comparison with AD in humans, and the full spectrum of AD effects has yet to be recapitulated in a single mouse model. The Model Organism Development and Evaluation for Late-Onset Alzheimer’s Disease (MODEL-AD) consortium was assembled by the National Institute on Aging (NIA) to develop more robust animal models of AD with increased relevance to human disease, standardize the characterization of AD mouse models, improve preclinical testing in animals, and establish clinically relevant AD biomarkers, among other aims toward enhancing the translational value of AD models in clinical drug design and treatment development. Here we have conducted a detailed characterization of the 5XFAD mouse, including transcriptomics, electroencephalogram, in vivo imaging, biochemical characterization, and behavioral assessments. The data from this study is publicly available through the AD Knowledge Portal. Frontiers Media S.A. 2021-07-23 /pmc/articles/PMC8346252/ /pubmed/34366832 http://dx.doi.org/10.3389/fnagi.2021.713726 Text en Copyright © 2021 Oblak, Lin, Kotredes, Pandey, Garceau, Williams, Uyar, O’Rourke, O’Rourke, Ingraham, Bednarczyk, Belanger, Cope, Little, Williams, Ash, Bleckert, Ragan, Logsdon, Mangravite, Sukoff Rizzo, Territo, Carter, Howell, Sasner and Lamb. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Oblak, Adrian L. Lin, Peter B. Kotredes, Kevin P. Pandey, Ravi S. Garceau, Dylan Williams, Harriet M. Uyar, Asli O’Rourke, Rita O’Rourke, Sarah Ingraham, Cynthia Bednarczyk, Daria Belanger, Melisa Cope, Zackary A. Little, Gabriela J. Williams, Sean-Paul G. Ash, Carl Bleckert, Adam Ragan, Tim Logsdon, Benjamin A. Mangravite, Lara M. Sukoff Rizzo, Stacey J. Territo, Paul R. Carter, Gregory W. Howell, Gareth R. Sasner, Michael Lamb, Bruce T. Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study |
title | Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study |
title_full | Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study |
title_fullStr | Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study |
title_full_unstemmed | Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study |
title_short | Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study |
title_sort | comprehensive evaluation of the 5xfad mouse model for preclinical testing applications: a model-ad study |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346252/ https://www.ncbi.nlm.nih.gov/pubmed/34366832 http://dx.doi.org/10.3389/fnagi.2021.713726 |
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