Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers

The RNA pseudoknot that stimulates programmed ribosomal frameshifting in SARS-CoV-2 is a possible drug target. To understand how it responds to mechanical tension applied by ribosomes, thought to play a key role during frameshifting, we probe its structural dynamics using optical tweezers. We find t...

Descripción completa

Detalles Bibliográficos
Autores principales: Neupane, Krishna, Zhao, Meng, Lyons, Aaron, Munshi, Sneha, Ileperuma, Sandaru M., Ritchie, Dustin B., Hoffer, Noel Q., Narayan, Abhishek, Woodside, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346527/
https://www.ncbi.nlm.nih.gov/pubmed/34362921
http://dx.doi.org/10.1038/s41467-021-25085-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346527/
https://www.ncbi.nlm.nih.gov/pubmed/34362921
http://dx.doi.org/10.1038/s41467-021-25085-6

Ejemplares similares