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Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers
The RNA pseudoknot that stimulates programmed ribosomal frameshifting in SARS-CoV-2 is a possible drug target. To understand how it responds to mechanical tension applied by ribosomes, thought to play a key role during frameshifting, we probe its structural dynamics using optical tweezers. We find t...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346527/ https://www.ncbi.nlm.nih.gov/pubmed/34362921 http://dx.doi.org/10.1038/s41467-021-25085-6 |