High-mass MALDI-MS unravels ligand-mediated G protein–coupling selectivity to GPCRs

G protein–coupled receptors (GPCRs) are important pharmaceutical targets for the treatment of a broad spectrum of diseases. Although there are structures of GPCRs in their active conformation with bound ligands and G proteins, the detailed molecular interplay between the receptors and their signalin...

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Detalles Bibliográficos
Autores principales: Wu, Na, Olechwier, Agnieszka M., Brunner, Cyrill, Edwards, Patricia C., Tsai, Ching-Ju, Tate, Christopher G., Schertler, Gebhard F. X., Schneider, Gisbert, Deupi, Xavier, Zenobi, Renato, Ma, Pikyee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346855/
https://www.ncbi.nlm.nih.gov/pubmed/34326250
http://dx.doi.org/10.1073/pnas.2024146118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346855/
https://www.ncbi.nlm.nih.gov/pubmed/34326250
http://dx.doi.org/10.1073/pnas.2024146118

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