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High-mass MALDI-MS unravels ligand-mediated G protein–coupling selectivity to GPCRs
G protein–coupled receptors (GPCRs) are important pharmaceutical targets for the treatment of a broad spectrum of diseases. Although there are structures of GPCRs in their active conformation with bound ligands and G proteins, the detailed molecular interplay between the receptors and their signalin...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346855/ https://www.ncbi.nlm.nih.gov/pubmed/34326250 http://dx.doi.org/10.1073/pnas.2024146118 |