Wild-type GBA1 increases the α-synuclein tetramer–monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice

Loss-of-function mutations in acid beta-glucosidase 1 (GBA1) are among the strongest genetic risk factors for Lewy body disorders such as Parkinson’s disease (PD) and Lewy body dementia (DLB). Altered lipid metabolism in PD patient–derived neurons, carrying either GBA1 or PD αS mutations, can shift...

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Detalles Bibliográficos
Autores principales: Glajch, Kelly E., Moors, Tim E., Chen, Yi, Bechade, Pascal A., Nam, Alice Y., Rajsombath, Molly M., McCaffery, Thomas D., Dettmer, Ulf, Weihofen, Andreas, Hirst, Warren D., Selkoe, Dennis J., Nuber, Silke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346893/
https://www.ncbi.nlm.nih.gov/pubmed/34326260
http://dx.doi.org/10.1073/pnas.2103425118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346893/
https://www.ncbi.nlm.nih.gov/pubmed/34326260
http://dx.doi.org/10.1073/pnas.2103425118

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