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A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective Na(V)1.8 Inhibitor, in Healthy Male Adults
OBJECTIVE: To evaluate the analgesic potential, safety, tolerability, and pharmacokinetics of VX-150, a pro-drug of a highly selective Na(V)1.8 inhibitor, in healthy subjects. DESIGN: This was a randomized, double-blind, placebo-controlled, crossover study in healthy subjects. SUBJECTS: Twenty healt...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346919/ https://www.ncbi.nlm.nih.gov/pubmed/33543763 http://dx.doi.org/10.1093/pm/pnab032 |