A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective Na(V)1.8 Inhibitor, in Healthy Male Adults

OBJECTIVE: To evaluate the analgesic potential, safety, tolerability, and pharmacokinetics of VX-150, a pro-drug of a highly selective Na(V)1.8 inhibitor, in healthy subjects. DESIGN: This was a randomized, double-blind, placebo-controlled, crossover study in healthy subjects. SUBJECTS: Twenty healt...

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Detalles Bibliográficos
Autores principales: Hijma, Hemme J, Siebenga, Pieter S, de Kam, Marieke L, Groeneveld, Geert Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Methodology, Mechanisms & Translational Research Section
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346919/
https://www.ncbi.nlm.nih.gov/pubmed/33543763
http://dx.doi.org/10.1093/pm/pnab032

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