Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1

The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of glucose homeostasis and has been successfully targeted for the treatment of type 2 diabetes. Recently described biased GLP-1R agonists with selective reductions in β-arrestin versus G protein coupling show improved metabolic...

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Detalles Bibliográficos
Autores principales: Marzook, Amaara, Chen, Shiqian, Pickford, Phil, Lucey, Maria, Wang, Yifan, Corrêa Jr, Ivan R., Broichhagen, Johannes, Hodson, David J., Salem, Victoria, Rutter, Guy A., Tan, Tricia M., Bloom, Stephen R., Tomas, Alejandra, Jones, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346945/
https://www.ncbi.nlm.nih.gov/pubmed/34129856
http://dx.doi.org/10.1016/j.bcp.2021.114656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346945/
https://www.ncbi.nlm.nih.gov/pubmed/34129856
http://dx.doi.org/10.1016/j.bcp.2021.114656

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