Identification of Spiro-Fused [3-azabicyclo[3.1.0]hexane]oxindoles as Potential Antitumor Agents: Initial In Vitro Evaluation of Anti-Proliferative Effect and Actin Cytoskeleton Transformation in 3T3 and 3T3-SV40 Fibroblast

Novel heterocyclic compounds containing 3-spiro[3-azabicyclo[3.1.0]hexane]oxindole framework (4a, 4b and 4c) have been studied as potential antitumor agents. The in silico ADMET (adsorption, distribution, metabolism, excretion and toxicity) analysis was performed on 4a–c compounds with promising ant...

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Detalles Bibliográficos
Autores principales: Knyazev, Nickolay A., Shmakov, Stanislav V., Pechkovskaya, Sofya A., Filatov, Alexander S., Stepakov, Alexander V., Boitsov, Vitali M., Filatova, Natalia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347490/
https://www.ncbi.nlm.nih.gov/pubmed/34361029
http://dx.doi.org/10.3390/ijms22158264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347490/
https://www.ncbi.nlm.nih.gov/pubmed/34361029
http://dx.doi.org/10.3390/ijms22158264

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