Synthesis and Biological Assessment of 4,1-Benzothiazepines with Neuroprotective Activity on the Ca(2+) Overload for the Treatment of Neurodegenerative Diseases and Stroke

In excitable cells, mitochondria play a key role in the regulation of the cytosolic Ca(2+) levels. A dysregulation of the mitochondrial Ca(2+) buffering machinery derives in serious pathologies, where neurodegenerative diseases highlight. Since the mitochondrial Na(+)/Ca(2+) exchanger (NCLX) is the...

Descripción completa

Detalles Bibliográficos
Autores principales: Viejo, Lucía, Rubio-Alarcón, Marcos, Arribas, Raquel L., Moreno-Castro, Manuel, Pérez-Marín, Raquel, Braun-Cornejo, María, Estrada-Valencia, Martín, de los Ríos, Cristóbal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347512/
https://www.ncbi.nlm.nih.gov/pubmed/34361628
http://dx.doi.org/10.3390/molecules26154473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347512/
https://www.ncbi.nlm.nih.gov/pubmed/34361628
http://dx.doi.org/10.3390/molecules26154473

Ejemplares similares