Cargando…

Synthesis and Biological Assessment of 4,1-Benzothiazepines with Neuroprotective Activity on the Ca(2+) Overload for the Treatment of Neurodegenerative Diseases and Stroke

In excitable cells, mitochondria play a key role in the regulation of the cytosolic Ca(2+) levels. A dysregulation of the mitochondrial Ca(2+) buffering machinery derives in serious pathologies, where neurodegenerative diseases highlight. Since the mitochondrial Na(+)/Ca(2+) exchanger (NCLX) is the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Viejo, Lucía, Rubio-Alarcón, Marcos, Arribas, Raquel L., Moreno-Castro, Manuel, Pérez-Marín, Raquel, Braun-Cornejo, María, Estrada-Valencia, Martín, de los Ríos, Cristóbal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347512/ https://www.ncbi.nlm.nih.gov/pubmed/34361628 http://dx.doi.org/10.3390/molecules26154473

Ejemplares similares

The Neuroprotector Benzothiazepine CGP37157 Extends Lifespan in C. elegans Worms
por: García-Casas, Paloma, et al.
Publicado: (2019)

In Silico Prediction of the Toxic Potential of Neuroprotective Bifunctional Molecules Based on Chiral N-Propargyl-1,2-amino Alcohol Derivatives
por: Ramos, Eva, et al.
Publicado: (2021)

Reversal of Cisplatin Resistance by the 1,4‐Benzothiazepine Derivative, JTV‐519
por: Nakamura, Takashi, et al.
Publicado: (2001)

3,4-Dihydro-1,4-benzothiazepin-5(2H)-one
por: Chen, Zhi-Long, et al.
Publicado: (2007)

(Z)-3-Benzyl-1,5-benzothiazepin-4(5H)-one
por: Sabari, V., et al.
Publicado: (2012)

3-(4-Methoxybenzyl)-1,5-benzothiazepin-4(5H)-one
por: Selvakumar, R., et al.
Publicado: (2013)

1,5-Benzothiazepine Derivatives: Green Synthesis, In Silico and In Vitro Evaluation as Anticancer Agents
por: Haroun, Michelyne, et al.
Publicado: (2022)

Mitochondrial Ca(2+) Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs
por: Sanz-Blasco, Sara, et al.
Publicado: (2008)

Vacuolar protein sorting protein 41 (VPS41) at an intersection of endosomal traffic in neurodegenerative disease
por: Griffin, Edward F., et al.
Publicado: (2019)

Disease modification and Neuroprotection in neurodegenerative disorders
por: Cummings, Jeffrey
Publicado: (2017)

Comparative Molecular Field Analysis of Benzothiazepine Derivatives: Mitochondrial Sodium Calcium Exchange Inhibitors as Antidiabetic Agents
por: Dasoondi, A. S., et al.
Publicado: (2008)

Prolactin-induced neuroprotection against glutamate excitotoxicity is mediated by the reduction of [Ca(2+)]i overload and NF-κB activation
por: Rivero-Segura, Nadia A., et al.
Publicado: (2017)

Neuroprotective Effect of Cyperi rhizome against Corticosterone-Induced PC12 Cell Injury via Suppression of Ca(2+) Overloading
por: Jia, Hongmei, et al.
Publicado: (2019)

(Z)-3-(4-Chlorobenzyl)-1,5-benzothiazepin-4(5H)-one
por: Lakshmanan, D., et al.
Publicado: (2012)

(Z)-3-(2-Chlorobenzyl)-1,5-benzothiazepin-4(5H)-one
por: Sabari, V., et al.
Publicado: (2012)

Molecular docking based screening of G6PS with 1, 5 Benzothiazepine derivates for a potential inhibitor
por: Chennu, Maruthi Malya Prasada Rao, et al.
Publicado: (2015)

Evaluation of 2,3-Dihydro-1,5-benzothiazepine Derivatives as Potential Tyrosinase Inhibitors: In Vitro and In Silico Studies
por: Al-Rooqi, Munirah M., et al.
Publicado: (2023)

Neuroprotective effects of berry fruits on neurodegenerative diseases
por: Subash, Selvaraju, et al.
Publicado: (2014)

Editorial: Unraveling Neuroprotective and Neurodegenerative Signals in Neurodegeneration
por: Vega, Irving E., et al.
Publicado: (2016)

Estrogen Interactions With Lipid Rafts Related to Neuroprotection. Impact of Brain Ageing and Menopause
por: Marin, Raquel, et al.
Publicado: (2018)

3-[(Z)-Benzylidene]-2,3-dihydro-1,5-benzothiazepin-4(5H)-one
por: Sabari, V., et al.
Publicado: (2011)

Stabilization of the Skeletal Muscle Ryanodine Receptor Ion Channel-FKBP12 Complex by the 1,4-Benzothiazepine Derivative S107
por: Mei, Yingwu, et al.
Publicado: (2013)

Neuroprotection by (Endo)Cannabinoids in Glaucoma and Retinal Neurodegenerative Diseases
por: Rapino, Cinzia, et al.
Publicado: (2018)

Neuroprotective mechanisms of 3-n-butylphthalide in neurodegenerative diseases
por: Luo, Rixin, et al.
Publicado: (2019)

Neuroprotective Properties of Food-Borne Polyphenols in Neurodegenerative Diseases
por: Silva, Rui F. M., et al.
Publicado: (2021)

SYK coordinates neuroprotective microglial responses in neurodegenerative disease
por: Ennerfelt, Hannah, et al.
Publicado: (2022)

Neuroprotective Effects of Neuropeptide Y against Neurodegenerative  Disease
por: Pain, Stéphanie, et al.
Publicado: (2022)

Polyphenols and Neurodegenerative Diseases: Potential Effects and Mechanisms of Neuroprotection
por: Arias-Sánchez, Raziel Alejandro, et al.
Publicado: (2023)

(Z)-3-(2-Methoxybenzyl)-1,5-benzothiazepin-4(5H)-one
por: Selvakumar, R., et al.
Publicado: (2012)

3-(2-Methylbenzylidene)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one
por: Sridevi, D., et al.
Publicado: (2011)

(Z)-3-(2,4-Dichlorobenzyl)-1,5-benzothiazepin-4(5H)-one
por: Murugavel, S., et al.
Publicado: (2013)

Iron overload and neurodegenerative diseases: What can we learn from Caenorhabditis elegans?
por: Martins, Airton C, et al.
Publicado: (2022)

Endogenous neuroprotection in chronic neurodegenerative disorders: with particular regard to the kynurenines
por: Zádori, Dénes, et al.
Publicado: (2011)

Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the Starting Point?
por: Benussi, Luisa, et al.
Publicado: (2017)

Neuroprotective Effects and Mechanisms of Tea Bioactive Components in Neurodegenerative Diseases
por: Chen, Shu-Qing, et al.
Publicado: (2018)

Neuroprotection in Neurodegenerative Disease: From Basic Science to Clinical Applications
por: Monteiro, Marta C., et al.
Publicado: (2017)

Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders
por: Machhi, Jatin, et al.
Publicado: (2020)

Histone Deacetylases Inhibitors in Neurodegenerative Diseases, Neuroprotection and Neuronal Differentiation
por: Shukla, Surabhi, et al.
Publicado: (2020)

Neuroprotective therapy for retinal neurodegenerative diseases by stem cell secretome
por: Usategui-Martín, Ricardo, et al.
Publicado: (2020)

PLGA-Based Nanoparticles for Neuroprotective Drug Delivery in Neurodegenerative Diseases
por: Cunha, Anthony, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_k86bckf3p0183rgnfh2ebonmb3