N-Skatyltryptamines—Dual 5-HT(6)R/D(2)R Ligands with Antipsychotic and Procognitive Potential

A series of N-skatyltryptamines was synthesized and their affinities for serotonin and dopamine receptors were determined. Compounds exhibited activity toward 5-HT(1A), 5-HT(2A), 5-HT(6), and D(2) receptors. Substitution patterns resulting in affinity/activity switches were identified and studied us...

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Detalles Bibliográficos
Autores principales: Hogendorf, Agata, Hogendorf, Adam S., Kurczab, Rafał, Satała, Grzegorz, Szewczyk, Bernadeta, Cieślik, Paulina, Latacz, Gniewomir, Handzlik, Jadwiga, Lenda, Tomasz, Kaczorowska, Katarzyna, Staroń, Jakub, Bugno, Ryszard, Duszyńska, Beata, Bojarski, Andrzej J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347595/
https://www.ncbi.nlm.nih.gov/pubmed/34361754
http://dx.doi.org/10.3390/molecules26154605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347595/
https://www.ncbi.nlm.nih.gov/pubmed/34361754
http://dx.doi.org/10.3390/molecules26154605

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