Detection of 4a,5-dihydropravastatin as Impurity in the Cholesterol Lowering Drug Pravastatin

Dihydro analogues are known byproducts of the fermentative production of statins and cannot be detected with existing pharmacopoeia analysis methods. We detected dihydropravastatin in most commercial formulations of pravastatin with LC-MS, in some cases in levels requiring identification. In ferment...

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Detalles Bibliográficos
Autores principales: van Scheppingen, Wibo B., Lankhorst, Peter P., Hans, Marcus, van den Berg, Marco A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347671/
https://www.ncbi.nlm.nih.gov/pubmed/34361838
http://dx.doi.org/10.3390/molecules26154685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347671/
https://www.ncbi.nlm.nih.gov/pubmed/34361838
http://dx.doi.org/10.3390/molecules26154685

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