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Computational Insights into the Deleterious Impacts of Missense Variants on N-Acetyl-d-glucosamine Kinase Structure and Function

An enzyme of the mammalian amino-sugar metabolism pathway, N-acetylglucosamine kinase (NAGK), that synthesizes N-acetylglucosamine (GlcNAc)-6-phosphate, is reported to promote dynein functions during mitosis, axonal and dendritic growth, cell migration, and selective autophagy, which all are unrelat...

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Detalles Bibliográficos
Autores principales: Dash, Raju, Mitra, Sarmistha, Munni, Yeasmin Akter, Choi, Ho Jin, Ali, Md. Chayan, Barua, Largess, Jang, Tae Jung, Moon, Il Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347710/
https://www.ncbi.nlm.nih.gov/pubmed/34360815
http://dx.doi.org/10.3390/ijms22158048