The Course of AαVal541 as a Proteinase 3 Specific Neo-Epitope after Alpha-1-Antitrypsin Augmentation in Severe Deficient Patients

In alpha-1-antitrypsin deficiency (AATD), neutrophil serine proteases such as elastase and proteinase 3 (PR3) are insufficiently inhibited. A previous study in AATD patients showed a higher plasma level of the specific PR3-generated fibrinogen-derived peptide AαVal541, compared with healthy controls...

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Detalles Bibliográficos
Autores principales: Schouten, Iris G. M., Mumford, Richard A., Moes, Dirk Jan A. R., Hiemstra, Pieter S., Stolk, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347723/
https://www.ncbi.nlm.nih.gov/pubmed/34360796
http://dx.doi.org/10.3390/ijms22158031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347723/
https://www.ncbi.nlm.nih.gov/pubmed/34360796
http://dx.doi.org/10.3390/ijms22158031

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