Antiproliferative Efficacy of N-(3-chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine, DW-8, in Colon Cancer Cells Is Mediated by Intrinsic Apoptosis

A novel series of 4-anilinoquinazoline analogues, DW (1–10), were evaluated for anticancer efficacy in human breast cancer (BT-20) and human colorectal cancer (CRC) cell lines (HCT116, HT29, and SW620). The compound, DW-8, had the highest anticancer efficacy and selectivity in the colorectal cancer...

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Detalles Bibliográficos
Autores principales: Neupane, Rabin, Malla, Saloni, Abou-Dahech, Mariam Sami, Balaji, Swapnaa, Kumari, Shikha, Waiker, Digambar Kumar, Moorthy, N. S. Hari Narayana, Trivedi, Piyush, Ashby, Charles R., Karthikeyan, Chandrabose, Tiwari, Amit K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347809/
https://www.ncbi.nlm.nih.gov/pubmed/34361570
http://dx.doi.org/10.3390/molecules26154417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347809/
https://www.ncbi.nlm.nih.gov/pubmed/34361570
http://dx.doi.org/10.3390/molecules26154417

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