Development of a Bispecific Antibody-Based Platform for Retargeting of Capsid Modified AAV Vectors

A major limiting factor for systemically delivered gene therapies is the lack of novel tissue specific AAV (Adeno-associated virus) derived vectors. Bispecific antibodies can be used to redirect AAVs to specific target receptors. Here, we demonstrate that the insertion of a short linear epitope “2E3...

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Detalles Bibliográficos
Autores principales: Kuklik, Juliane, Michelfelder, Stefan, Schiele, Felix, Kreuz, Sebastian, Lamla, Thorsten, Müller, Philipp, Park, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347852/
https://www.ncbi.nlm.nih.gov/pubmed/34361120
http://dx.doi.org/10.3390/ijms22158355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347852/
https://www.ncbi.nlm.nih.gov/pubmed/34361120
http://dx.doi.org/10.3390/ijms22158355

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