Cell line development for continuous high cell density biomanufacturing: Exploiting hypoxia for improved productivity

Oxygen deficiency (hypoxia) induces adverse effects during biotherapeutic protein production leading to reduced productivity and cell growth. Hypoxic conditions occur during classical batch fermentations using high cell densities or perfusion processes. Here we present an effort to create novel engi...

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Detalles Bibliográficos
Autores principales: Zeh, Nikolas, Schlossbauer, Patrick, Raab, Nadja, Klingler, Florian, Handrick, René, Otte, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348152/
https://www.ncbi.nlm.nih.gov/pubmed/34401326
http://dx.doi.org/10.1016/j.mec.2021.e00181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348152/
https://www.ncbi.nlm.nih.gov/pubmed/34401326
http://dx.doi.org/10.1016/j.mec.2021.e00181

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