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Cell line development for continuous high cell density biomanufacturing: Exploiting hypoxia for improved productivity
Oxygen deficiency (hypoxia) induces adverse effects during biotherapeutic protein production leading to reduced productivity and cell growth. Hypoxic conditions occur during classical batch fermentations using high cell densities or perfusion processes. Here we present an effort to create novel engi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348152/ https://www.ncbi.nlm.nih.gov/pubmed/34401326 http://dx.doi.org/10.1016/j.mec.2021.e00181 |