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Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology

Biofilms, the predominant growth mode of microorganisms, pose a significant risk to human health. The protective biofilm matrix, typically composed of exopolysaccharides, proteins, nucleic acids, and lipids, combined with biofilm-grown bacteria’s heterogenous physiology, leads to enhanced fitness an...

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Detalles Bibliográficos
Autores principales: Trebino, Michael A., Shingare, Rahul D., MacMillan, John B., Yildiz, Fitnat H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348372/
https://www.ncbi.nlm.nih.gov/pubmed/34361735
http://dx.doi.org/10.3390/molecules26154582
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author Trebino, Michael A.
Shingare, Rahul D.
MacMillan, John B.
Yildiz, Fitnat H.
author_facet Trebino, Michael A.
Shingare, Rahul D.
MacMillan, John B.
Yildiz, Fitnat H.
author_sort Trebino, Michael A.
collection PubMed
description Biofilms, the predominant growth mode of microorganisms, pose a significant risk to human health. The protective biofilm matrix, typically composed of exopolysaccharides, proteins, nucleic acids, and lipids, combined with biofilm-grown bacteria’s heterogenous physiology, leads to enhanced fitness and tolerance to traditional methods for treatment. There is a need to identify biofilm inhibitors using diverse approaches and targeting different stages of biofilm formation. This review discusses discovery strategies that successfully identified a wide range of inhibitors and the processes used to characterize their inhibition mechanism and further improvement. Additionally, we examine the structure–activity relationship (SAR) for some of these inhibitors to optimize inhibitor activity.
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spelling pubmed-83483722021-08-08 Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology Trebino, Michael A. Shingare, Rahul D. MacMillan, John B. Yildiz, Fitnat H. Molecules Review Biofilms, the predominant growth mode of microorganisms, pose a significant risk to human health. The protective biofilm matrix, typically composed of exopolysaccharides, proteins, nucleic acids, and lipids, combined with biofilm-grown bacteria’s heterogenous physiology, leads to enhanced fitness and tolerance to traditional methods for treatment. There is a need to identify biofilm inhibitors using diverse approaches and targeting different stages of biofilm formation. This review discusses discovery strategies that successfully identified a wide range of inhibitors and the processes used to characterize their inhibition mechanism and further improvement. Additionally, we examine the structure–activity relationship (SAR) for some of these inhibitors to optimize inhibitor activity. MDPI 2021-07-29 /pmc/articles/PMC8348372/ /pubmed/34361735 http://dx.doi.org/10.3390/molecules26154582 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Trebino, Michael A.
Shingare, Rahul D.
MacMillan, John B.
Yildiz, Fitnat H.
Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology
title Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology
title_full Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology
title_fullStr Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology
title_full_unstemmed Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology
title_short Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology
title_sort strategies and approaches for discovery of small molecule disruptors of biofilm physiology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348372/
https://www.ncbi.nlm.nih.gov/pubmed/34361735
http://dx.doi.org/10.3390/molecules26154582
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