Cargando…

Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology

Biofilms, the predominant growth mode of microorganisms, pose a significant risk to human health. The protective biofilm matrix, typically composed of exopolysaccharides, proteins, nucleic acids, and lipids, combined with biofilm-grown bacteria’s heterogenous physiology, leads to enhanced fitness an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Trebino, Michael A., Shingare, Rahul D., MacMillan, John B., Yildiz, Fitnat H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348372/ https://www.ncbi.nlm.nih.gov/pubmed/34361735 http://dx.doi.org/10.3390/molecules26154582

Ejemplares similares

A label-free approach for relative spatial quantitation of c-di-GMP in microbial biofilms
por: McCaughey, Catherine S., et al.
Publicado: (2023)

Synthesis and Investigation of the Abiotic Formation of Pyonitrins A–D
por: Shingare, Rahul D., et al.
Publicado: (2020)

The Rvv two-component regulatory system regulates biofilm formation and colonization in Vibrio cholerae
por: Kitts, Giordan, et al.
Publicado: (2023)

Biomimetic Total Synthesis and Investigation of the Non‐Enzymatic Chemistry of Oxazinin A
por: Aniebok, Victor, et al.
Publicado: (2022)

Synthesis and Activity of Biomimetic Biofilm Disruptors
por: Böttcher, Thomas, et al.
Publicado: (2013)

Inhibition of a Viral Enzyme by a Small Molecule Dimer Disruptor
por: Shahian, Tina, et al.
Publicado: (2009)

Panspecies Small-Molecule Disruptors of Heterochromatin-Mediated Transcriptional Gene Silencing
por: Castonguay, Emilie, et al.
Publicado: (2015)

National strategy on endocrine disruptors.
Publicado: (1996)

Strategies for Discovery of Small Molecule Radiation Protectors and Radiation Mitigators
por: Greenberger, Joel S., et al.
Publicado: (2012)

Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib
por: Bagnolini, Greta, et al.
Publicado: (2020)

Exploration of small-molecule entry disruptors for chikungunya virus by targeting matrix remodelling associated protein
por: Kumar, Avinash, et al.
Publicado: (2020)

Identifying disruptors of male germ cell development by small molecule screening in ex vivo gonad cultures
por: Wakeling, Stephanie I, et al.
Publicado: (2013)

Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)
por: Seralini, Gilles-Eric, et al.
Publicado: (2021)

Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae
por: Warner, Christopher J. A., et al.
Publicado: (2015)

Effect of antimicrobial nanocomposites on Vibrio cholerae lifestyles: Pellicle biofilm, planktonic and surface-attached biofilm
por: Meza-Villezcas, Anaid, et al.
Publicado: (2019)

Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain
por: Gadotti, Vinicius M, et al.
Publicado: (2015)

Synthesis and Structure–Activity Relationship Studies of Small Molecule Disruptors of EWS-FLI1 Interactions in Ewing’s Sarcoma
por: Tosso, Perrer N., et al.
Publicado: (2014)

Hierarchical virtual screening approaches in small molecule drug discovery
por: Kumar, Ashutosh, et al.
Publicado: (2015)

Long-Term Effects of Environmental Endocrine Disruptors on Reproductive Physiology and Behavior
por: Patisaul, Heather B., et al.
Publicado: (2009)

Heat Stress: A Serious Disruptor of the Reproductive Physiology of Dairy Cows
por: Dovolou, Eleni, et al.
Publicado: (2023)

Small-Molecule Inhibition of Bacterial Biofilm
por: Ghosh, Anirban, et al.
Publicado: (2020)

Role of Vibrio polysaccharide (vps) genes in VPS production, biofilm formation and Vibrio cholerae pathogenesis
por: Fong, Jiunn C. N., et al.
Publicado: (2010)

Exposure to endocrine disruptors promotes biofilm formation and contributes to increased virulence of Pseudomonas aeruginosa
por: Thiroux, Audrey, et al.
Publicado: (2023)

Transforming infoglut!: a pragmatic strategy for Oracle Enterprise content management
por: MacMillan, Andy, et al.
Publicado: (2009)

A Biomimetic Polyketide-Inspired Approach to Small Molecule Ligand Discovery
por: Aquino, Claudio, et al.
Publicado: (2011)

Editorial: Organotins as a Complete Physiologic and Endocrine Disruptor: Role of Disease Development
por: Graceli, Jones Bernardes
Publicado: (2019)

Effectiveness of Efflux Pump Inhibitors as Biofilm Disruptors and Resistance Breakers in Gram-Negative (ESKAPEE) Bacteria
por: Reza, Akif, et al.
Publicado: (2019)

Endocrine Disruptors and Obesity
por: Darbre, Philippa D.
Publicado: (2017)

The entrepreneurial mindset: strategies for continuously creating opportunity in an age of uncertainty
por: McGrath, Rita Gunther, et al.
Publicado: (2000)

A Machine Learning Strategy for Drug Discovery Identifies Anti-Schistosomal Small Molecules
por: Zorn, Kimberley M., et al.
Publicado: (2021)

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
por: Heller, Gabriella T., et al.
Publicado: (2020)

Endocrine disruptors in plastics alter β-cell physiology and increase the risk of diabetes mellitus
por: Martínez-Pinna, Juan, et al.
Publicado: (2023)

Issue analysis: key characteristics approach for identifying endocrine disruptors
por: Borgert, Christopher J.
Publicado: (2023)

Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens
por: Clausse, Victor, et al.
Publicado: (2019)

Endocrine disruptors : effects on male and female reproductive systems /
Publicado: (2005)

Discovery of Nanomolar DCAF1 Small Molecule Ligands
por: Li, Alice Shi Ming, et al.
Publicado: (2023)

Small Molecule Anti-biofilm Agents Developed on the Basis of Mechanistic Understanding of Biofilm Formation
por: Qvortrup, Katrine, et al.
Publicado: (2019)

Emerging Research on Endocrine Disruptors
por: Schwartz, David A., et al.
Publicado: (2007)

Priorities for endocrine disruptor research.
Publicado: (1997)

Endocrine disruptors and testis development.
por: Sharpe, R M, et al.
Publicado: (1998)

Cannot write session to /tmp/vufind_sessions/sess_ilj3u9fud74r2mfoqbjgmj36ss