Divalent Metal Transporter 1 Knock-Down Modulates IL-1β Mediated Pancreatic Beta-Cell Pro-Apoptotic Signaling Pathways through the Autophagic Machinery

Pro-inflammatory cytokines promote cellular iron-import through enhanced divalent metal transporter-1 (DMT1) expression in pancreatic β-cells, consequently cell death. Inhibition of β-cell iron-import by DMT1 silencing protects against apoptosis in animal models of diabetes. However, how alterations...

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Detalles Bibliográficos
Autores principales: Kang, Taewook, Huang, Honggang, Mandrup-Poulsen, Thomas, Larsen, Martin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348373/
https://www.ncbi.nlm.nih.gov/pubmed/34360779
http://dx.doi.org/10.3390/ijms22158013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348373/
https://www.ncbi.nlm.nih.gov/pubmed/34360779
http://dx.doi.org/10.3390/ijms22158013

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