Eco-Friendly UPLC–MS/MS Method for Determination of a Fostamatinib Metabolite, Tamatinib, in Plasma: Pharmacokinetic Application in Rats

Fostamatinib is a prodrug of the active metabolite tamatinib, which is a spleen tyrosine kinase (Syk) inhibitor used in the treatment of primary chronic adult immune thrombocytopenia and rheumatoid arthritis. A highly sensitive, rapid, reliable, and green method was developed and validated using ult...

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Detalles Bibliográficos
Autores principales: Ezzeldin, Essam, Iqbal, Muzaffar, Asiri, Yousif A., Sayed, Ahmed Y. A., Alsalahi, Rashad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348403/
https://www.ncbi.nlm.nih.gov/pubmed/34361816
http://dx.doi.org/10.3390/molecules26154663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348403/
https://www.ncbi.nlm.nih.gov/pubmed/34361816
http://dx.doi.org/10.3390/molecules26154663

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