Indomethacin Disrupts the Formation of β-Amyloid Plaques via an α2-Macroglobulin-Activating lrp1-Dependent Mechanism

Epidemiological studies have implied that the nonsteroidal anti-inflammatory drug (NSAID) indomethacin slows the development and progression of Alzheimer’s disease (AD). However, the underlying mechanisms are notably understudied. Using a chimeric mouse/human amyloid precursor protein (Mo/HuAPP695sw...

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Detalles Bibliográficos
Autores principales: Guan, Pei-Pei, Yang, Liu-Qing, Xu, Guo-Biao, Wang, Pu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348656/
https://www.ncbi.nlm.nih.gov/pubmed/34360951
http://dx.doi.org/10.3390/ijms22158185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348656/
https://www.ncbi.nlm.nih.gov/pubmed/34360951
http://dx.doi.org/10.3390/ijms22158185

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