Novel Aptamer-Based Small-Molecule Drug Screening Assay to Identify Potential Sclerostin Inhibitors against Osteoporosis

A novel aptamer-based competitive drug screening platform for osteoporosis was devised in which fluorescence-labeled, sclerostin-specific aptamers compete with compounds from selected chemical libraries for the binding of immobilized recombinant human sclerostin to achieve high-throughput screening...

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Detalles Bibliográficos
Autores principales: Lee, Chien-Ching, Hung, Chao-Ming, Chen, Chung-Hwan, Hsu, Yi-Chiang, Huang, Yuan-Pin, Huang, Tsung-Bin, Lee, Mon-Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348959/
https://www.ncbi.nlm.nih.gov/pubmed/34361085
http://dx.doi.org/10.3390/ijms22158320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348959/
https://www.ncbi.nlm.nih.gov/pubmed/34361085
http://dx.doi.org/10.3390/ijms22158320

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