LPS-Induced Inflammation Affects Midazolam Clearance in Juvenile Mice in an Age-Dependent Manner

PURPOSE: Inflammation has a significant impact on CYP3A activity. We hypothesized that this effect might be age dependent. Our objective was to conduct a population pharmacokinetic study of midazolam in mice at different developmental stages with varying degrees of inflammation to verify our hypothe...

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Detalles Bibliográficos
Autores principales: Zheng, Yi, Ye, Pan-Pan, Zhou, Yue, Wu, Su-Ying, Liu, Xi-Ting, Du, Bin, Tang, Bo-Hao, Kan, Min, Nie, Ai-Qing, Yin, Rui, Wang, Meng, Hao, Guo-Xiang, Song, Lin-Lin, Yang, Xin-Mei, Huang, Xin, Su, Le-Qun, Wang, Wen-Qi, van den Anker, John, Zhao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349217/
https://www.ncbi.nlm.nih.gov/pubmed/34377007
http://dx.doi.org/10.2147/JIR.S321492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349217/
https://www.ncbi.nlm.nih.gov/pubmed/34377007
http://dx.doi.org/10.2147/JIR.S321492

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