A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with elevated potency

The SARS-CoV-2 receptor angiotensin converting enzyme 2 (ACE2) was previously engineered into a high affinity tetravalent format (ACE2-Fc-TD) that is a potential decoy protein in SARS-CoV-2 infection.We report that this protein shows greatly enhanced binding to SARS-CoV-2 spike proteins of the SARS-...

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Detalles Bibliográficos
Autores principales: Leach, Adam, Ilca, F. Tudor, Akbar, Zulaikha, Ferrari, Mathieu, Bentley, Emma M., Mattiuzzo, Giada, Onuoha, Shimobi, Miller, Ami, Ali, Hanif, Rabbitts, Terence H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349458/
https://www.ncbi.nlm.nih.gov/pubmed/34375715
http://dx.doi.org/10.1016/j.antiviral.2021.105147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349458/
https://www.ncbi.nlm.nih.gov/pubmed/34375715
http://dx.doi.org/10.1016/j.antiviral.2021.105147

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