Cargando…

A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with elevated potency

The SARS-CoV-2 receptor angiotensin converting enzyme 2 (ACE2) was previously engineered into a high affinity tetravalent format (ACE2-Fc-TD) that is a potential decoy protein in SARS-CoV-2 infection.We report that this protein shows greatly enhanced binding to SARS-CoV-2 spike proteins of the SARS-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leach, Adam, Ilca, F. Tudor, Akbar, Zulaikha, Ferrari, Mathieu, Bentley, Emma M., Mattiuzzo, Giada, Onuoha, Shimobi, Miller, Ami, Ali, Hanif, Rabbitts, Terence H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Published by Elsevier B.V. 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349458/ https://www.ncbi.nlm.nih.gov/pubmed/34375715 http://dx.doi.org/10.1016/j.antiviral.2021.105147

Ejemplares similares

A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection
por: Miller, Ami, et al.
Publicado: (2021)

Characterization of a Novel ACE2-Based Therapeutic with Enhanced Rather than Reduced Activity against SARS-CoV-2 Variants
por: Ferrari, Mathieu, et al.
Publicado: (2021)

Implementing a method for engineering multivalency to substantially enhance binding of clinical trial anti-SARS-CoV-2 antibodies to wildtype spike and variants of concern proteins
por: Leach, Adam, et al.
Publicado: (2021)

Multimeric antibodies with increased valency surpassing functional affinity and potency thresholds using novel formats
por: Miller, Ami, et al.
Publicado: (2020)

IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody
por: Saito, Shinji, et al.
Publicado: (2019)

The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins
por: Conceicao, Carina, et al.
Publicado: (2020)

Rational Design of Antirheumatic Prodrugs Specific for Sites of Inflammation
por: Onuoha, Shimobi C., et al.
Publicado: (2015)

The Role of Reference Materials in the Research and Development of Diagnostic Tools and Treatments for Haemorrhagic Fever Viruses
por: Mattiuzzo, Giada, et al.
Publicado: (2019)

More Than Just Gene Therapy Vectors: Lentiviral Vector Pseudotypes for Serological Investigation
por: Toon, Kamilla, et al.
Publicado: (2021)

SARS-CoV-2 omicron spike simulations: broad antibody escape, weakened ACE2 binding, and modest furin cleavage
por: Jawaid, M. Zaki, et al.
Publicado: (2023)

Spike residue 403 affects binding of coronavirus spikes to human ACE2
por: Zech, Fabian, et al.
Publicado: (2021)

Alterations to the broad-spectrum formin inhibitor SMIFH2 modulate potency but not specificity
por: Orman, Marina, et al.
Publicado: (2022)

Pentameric assembly of the Kv2.1 tetramerization domain
por: Xu, Zhen, et al.
Publicado: (2022)

Piers′ Borane‐Induced Tetramerization of Arylacetylenes
por: Hasenbeck, Max, et al.
Publicado: (2021)

An abiotic, tetrameric, eight-helix bundle
por: Menke, Friedericke S., et al.
Publicado: (2023)

Ceftazidime exhibits a broad inhibition to the infection of SARS-CoV-2 prototype and Omicron variant in vitro by blocking spike protein-ACE2 interaction
por: Zheng, Yun-zhe, et al.
Publicado: (2023)

Bee venom-derived antimicrobial peptide melectin has broad-spectrum potency, cell selectivity, and salt-resistant properties
por: Ko, Su Jin, et al.
Publicado: (2020)

Enhancing the Antiviral Potency of Nucleobases for Potential Broad-Spectrum Antiviral Therapies
por: Soto-Acosta, Ruben, et al.
Publicado: (2021)

The glycosylation status of MHC class I molecules impacts their interactions with TAPBPR
por: Ilca, F. Tudor, et al.
Publicado: (2021)

Structural Basis for Functional Tetramerization of Lentiviral Integrase
por: Hare, Stephen, et al.
Publicado: (2009)

Tetramerization Reinforces the Dimer Interface of MnSOD
por: Sheng, Yuewei, et al.
Publicado: (2013)

Tracing the Evolution of the p53 Tetramerization Domain
por: Joerger, Andreas C., et al.
Publicado: (2014)

ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker
por: Chen, Yuning, et al.
Publicado: (2021)

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry
por: Park, Young-Jun, et al.
Publicado: (2021)

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry
por: Park, Young-Jun, et al.
Publicado: (2022)

The inhibitory effect of a coronavirus spike protein fragment with ACE2
por: Peter, Emanuel K., et al.
Publicado: (2021)

Structures of the Omicron Spike trimer with ACE2 and an anti-Omicron antibody
por: Yin, Wanchao, et al.
Publicado: (2022)

SARS-CoV-2 spike and ACE2 entanglement-like binding
por: Pregnolato, Massimo, et al.
Publicado: (2023)

CO(2)-Responsive Wormlike Micelles Based on Pseudo-Tetrameric Surfactant
por: Wei, Xia, et al.
Publicado: (2022)

Broad-Spectrum Small-Molecule Inhibitors of the SARS-CoV-2 Spike—ACE2 Protein–Protein Interaction from a Chemical Space of Privileged Protein Binders
por: Chuang, Sung-Ting, et al.
Publicado: (2022)

Studies with bioengineered Nisin peptides highlight the broad‐spectrum potency of Nisin V
por: Field, Des, et al.
Publicado: (2010)

Chloroquine and Hydroxychloroquine Interact Differently with ACE2 Domains Reported to Bind with the Coronavirus Spike Protein: Mediation by ACE2 Polymorphism
por: Badraoui, Riadh, et al.
Publicado: (2021)

SARS-CoV-2 Spike mutations modify the interaction between virus Spike and human ACE2 receptors
por: Mishra, Pushpendra Mani, et al.
Publicado: (2022)

Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection
por: Luan, Junwen, et al.
Publicado: (2020)

LMO2 at 25 years: a paradigm of chromosomal translocation proteins
por: Chambers, Jennifer, et al.
Publicado: (2015)

Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor
por: Capraz, Tümay, et al.
Publicado: (2021)

A Rapamycin-Activated Caspase 9-Based Suicide Gene
por: Stavrou, Maria, et al.
Publicado: (2018)

Tetrameric Structure of Centromeric Nucleosomes in Interphase Drosophila Cells
por: Dalal, Yamini, et al.
Publicado: (2007)

Structure and Kinetic Stability of the p63 Tetramerization Domain
por: Natan, Eviatar, et al.
Publicado: (2012)

Structural studies of ion selectivity in tetrameric cation channels
por: Alam, Amer, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_kj37kqsihim3trpetqhv7cn2b6