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The combined effect of dichloroacetate and 3-bromopyruvate on glucose metabolism in colorectal cancer cell line, HT-29; the mitochondrial pathway apoptosis

BACKGROUND: 5-Fluorouracil (5-FU) is regarded as the first line treatment for colorectal cancer; however, its effectiveness is limited by drug resistance. The ultimate goal of cancer therapy is induction of cancer cell death to achieve an effective outcome with minimal side effects. The present work...

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Detalles Bibliográficos
Autores principales: Nikravesh, Hojatolla, Khodayar, Mohammad Javad, Behmanesh, Babak, Mahdavinia, Masoud, Teimoori, Ali, Alboghobeish, Soheila, Zeidooni, Leila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349486/
https://www.ncbi.nlm.nih.gov/pubmed/34364387
http://dx.doi.org/10.1186/s12885-021-08564-3