Base editing‐mediated perturbation of endogenous PKM1/2 splicing facilitates isoform‐specific functional analysis in vitro and in vivo

OBJECTIVES: PKM1 and PKM2, which are generated from the alternative splicing of PKM gene, play important roles in tumourigenesis and embryonic development as rate‐limiting enzymes in glycolytic pathway. However, because of the lack of appropriate techniques, the specific functions of the 2 PKM splic...

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Detalles Bibliográficos
Autores principales: Lin, Jianxiang, Wu, Susu, Shen, Qingmei, Liu, Jie, Huang, Shisheng, Peng, Guangdun, Qiao, Yunbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349652/
https://www.ncbi.nlm.nih.gov/pubmed/34240779
http://dx.doi.org/10.1111/cpr.13096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349652/
https://www.ncbi.nlm.nih.gov/pubmed/34240779
http://dx.doi.org/10.1111/cpr.13096

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