Transgenic mice for in vivo epigenome editing with CRISPR-based systems

CRISPR-Cas9 technologies have dramatically increased the ease of targeting DNA sequences in the genomes of living systems. Fusion of chromatin-modifying domains to the nuclease-deactivated dCas9 has enabled targeted epigenome editing in both cultured cells and animal models. However, delivering larg...

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Detalles Bibliográficos
Autores principales: Gemberling, Matthew P., Siklenka, Keith, Rodriguez, Erica, Tonn-Eisinger, Katherine R., Barrera, Alejandro, Liu, Fang, Kantor, Ariel, Li, Liqing, Cigliola, Valentina, Hazlett, Mariah F., Williams, Courtney A., Bartelt, Luke C., Madigan, Victoria J., Bodle, Josephine C., Daniels, Heather, Rouse, Douglas C., Hilton, Isaac B., Asokan, Aravind, Ciofani, Maria, Poss, Kenneth D., Reddy, Timothy E., West, Anne E., Gersbach, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349887/
https://www.ncbi.nlm.nih.gov/pubmed/34341582
http://dx.doi.org/10.1038/s41592-021-01207-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349887/
https://www.ncbi.nlm.nih.gov/pubmed/34341582
http://dx.doi.org/10.1038/s41592-021-01207-2

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