Hypoxia induces inflammatory microenvironment by priming specific macrophage polarization and modifies LSC behaviour via VEGF-HIF1α signalling

BACKGROUND: Leukemia stem cells (LSCs) play pivotal roles in leukemogenesis, and are closely implicated in leukemia relapse and chemoresistance. LSCs are tightly modulated by hypoxic exposure and macrophage-conditioned microenvironment. Nevertheless, the impacts on the biology of LSCs imposed by the...

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Detalles Bibliográficos
Autores principales: Jiang, Mingyan, He, Guoqian, Wang, Jialing, Guo, Xia, Zhao, Ziyi, Gao, Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349958/
https://www.ncbi.nlm.nih.gov/pubmed/34430427
http://dx.doi.org/10.21037/tp-21-86

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349958/
https://www.ncbi.nlm.nih.gov/pubmed/34430427
http://dx.doi.org/10.21037/tp-21-86

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