The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases – A Mini Review

Inflammation plays a central role in cardiovascular diseases (CVD). One pathway under investigation is the innate immune DNA sensor cyclic GMP-AMP synthase (cGAS) and its downstream receptor stimulator of interferon genes (STING). cGAS-STING upregulates type I interferons in response to pathogens. R...

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Detalles Bibliográficos
Autores principales: Rech, Lavinia, Rainer, Peter P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349977/
https://www.ncbi.nlm.nih.gov/pubmed/34381828
http://dx.doi.org/10.3389/fcvm.2021.715903
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author Rech, Lavinia
Rainer, Peter P.
author_facet Rech, Lavinia
Rainer, Peter P.
author_sort Rech, Lavinia
collection PubMed
description Inflammation plays a central role in cardiovascular diseases (CVD). One pathway under investigation is the innate immune DNA sensor cyclic GMP-AMP synthase (cGAS) and its downstream receptor stimulator of interferon genes (STING). cGAS-STING upregulates type I interferons in response to pathogens. Recent studies show that also self-DNA may activate cGAS-STING, for instance, DNA released from nuclei or mitochondria during obesity or myocardial infarction. Here, we focus on emerging evidence describing the interaction of cGAS-STING with cardiovascular risk factors and disease. We also touch on translational therapeutic opportunities and potential further investigations.
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spelling pubmed-83499772021-08-10 The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases – A Mini Review Rech, Lavinia Rainer, Peter P. Front Cardiovasc Med Cardiovascular Medicine Inflammation plays a central role in cardiovascular diseases (CVD). One pathway under investigation is the innate immune DNA sensor cyclic GMP-AMP synthase (cGAS) and its downstream receptor stimulator of interferon genes (STING). cGAS-STING upregulates type I interferons in response to pathogens. Recent studies show that also self-DNA may activate cGAS-STING, for instance, DNA released from nuclei or mitochondria during obesity or myocardial infarction. Here, we focus on emerging evidence describing the interaction of cGAS-STING with cardiovascular risk factors and disease. We also touch on translational therapeutic opportunities and potential further investigations. Frontiers Media S.A. 2021-07-26 /pmc/articles/PMC8349977/ /pubmed/34381828 http://dx.doi.org/10.3389/fcvm.2021.715903 Text en Copyright © 2021 Rech and Rainer. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Rech, Lavinia
Rainer, Peter P.
The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases – A Mini Review
title The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases – A Mini Review
title_full The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases – A Mini Review
title_fullStr The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases – A Mini Review
title_full_unstemmed The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases – A Mini Review
title_short The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases – A Mini Review
title_sort innate immune cgas-sting-pathway in cardiovascular diseases – a mini review
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349977/
https://www.ncbi.nlm.nih.gov/pubmed/34381828
http://dx.doi.org/10.3389/fcvm.2021.715903
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